hicstatistics

A compound heterozygous mutation of the alkaline phosphatase ALPL gene causes hypophosphatasia in a Han Chinese family

Hypophosphatasia (HPP) is a uncommon hereditary systemic illness that’s characterised by faulty bone and/or dental mineralization, and is brought on by mutations within the alkaline phosphatase gene (ALPL). The current examine investigated the ALPL mutation in a Chinese language Han household with HPP and studied the pathogenesis of the mutations of the ALPL gene. DNA was extracted from peripheral venous blood of the members of the family. Sanger sequencing was used to display the mutations.

Associations between pathogenesis for each mutations had been analyzed by bioinformatics, subcellular localization, measurement of enzyme exercise and western blotting. Sanger sequencing revealed the compound heterozygous mutations c.203C>T (p.T68M) and c.571G>A (p.E191Okay). The mutations had been positioned at exon four and 6 of the ALPL gene and had been predicted by Polyphen-2 evaluation to be dangerous. Protein evaluation indicated a lower in mature protein manufacturing and decrease enzyme exercise in 293T cells transfected with plasmids carrying the mutations.

The ALPL gene was cloned into the pcDNA3.1(+) vector and mutant plasmids ALPL-pT68M and ALPL-pE191Okay had been constructed. Immunofluorescence noticed in cells transfected with the ALPL-pE191Okay mutant plasmid was primarily positioned within the cell membrane. Nonetheless, staining within the cytoplasm was elevated in contrast with the wild kind, and nearly no fluorescence was recognized in 293T cells transfected with the ALPL-pT68M mutant plasmid. The current findings demonstrated that the compound heterozygous c.571G>A and c.203C>T mutations might contribute to childhood HPP by leading to mislocalization, decreased protein expression and lack of enzyme exercise in a Han Chinese language household. The outcomes of the present examine might present insights into the potential molecular mechanism of HPP.

 

Identification of Signatures of Choice by Entire-Genome Resequencing of a Chinese language Native Pig

Identification of genomic signatures of choice that assist reveal genetic mechanisms underlying traits in domesticated pigs is of significance. Anqing six-end-white pig (ASP), a consultant of the native breeds in China, has many distinguishing phenotypic traits. To establish the genomic signatures of choice of the ASP, whole-genome sequencing of 20 ASPs produced 469.01 Gb of sequence knowledge and greater than 26 million single-nucleotide polymorphisms.

Combining these knowledge with the out there complete genomes of 13 Chinese language wild boars, 157 chosen areas harboring 48 protein-coding genes had been recognized by making use of the polymorphism ranges (θπ) and genetic differentiation (F ST ) based mostly cross approaches.

The genes discovered to be positively chosen in ASP are concerned in essential organic processes reminiscent of coat colour ( MC1R ), salivary secretion ( STATH ), copy ( SPIRE2 , OSBP2 , LIMK2 , FANCA , and CABS1 ), olfactory transduction ( OR5K4 ), and development ( NPY1R , NPY5R , and SELENOM ). Our analysis elevated the data of ASP phenotype-related genes and assist to enhance our understanding of the underlying organic mechanisms and supply helpful genetic assets that allow efficient use of pigs in agricultural manufacturing.

Is CHEK2 a moderate-risk breast most cancers gene or the youthful sister of Li-Fraumeni?

 

The CHEK2 gene is usually thought-about as a average breast most cancers gene with the outcome that many clinicians have a slender focus. We current the 10-year journey of a person who had 5 completely different cancers and had iterative genetic testing together with for Li-Fraumeni syndrome, finally to find a pathogenic variant within the CHEK2 gene, presumably explaining his quite a few cancers. This prognosis supplied him closure which he had desperately searched for properly over a decade.

A pathogenic variant within the CHEK2 gene can doubtlessly clarify these cancers due to its operate as a tumour suppressor gene. Consideration is warranted of what this implies for people with CHEK2 variants who might develop a number of cancers, their prognosis and whether or not completely different therapy modalities reminiscent of chemotherapy, radiotherapy or goal brokers would wish modification. We encourage extra analysis into the various faces of the CHEK2 gene and the potential for predisposition to a number of cancers.

 

Purposeful classification of prostate most cancers‑related miRNAs by CRISPR/Cas9‑mediated gene knockout

 

The purpose of the current examine was to make use of the clustered repeatedly interspaced brief palindromic repeats (CRISPR) and CRISPR‑related (Cas) 9‑mediated gene knockout know-how for the speedy classification of the differential operate of micro (mi)RNAs screened utilizing miRNA expression profiling by microarray. The rational design of single information RNAs for the CRISPR/Cas9 system was verified to operate in human LNCaP cells with speedy and environment friendly goal gene modifying.

miRNA (miR)‑205, miR‑221, miR‑222, miR‑30c, miR‑224, miR‑455‑3p, miR‑23b and miR‑505 had been downregulated in sufferers with prostate most cancers (PCa) and had been experimentally validated to operate as tumor suppressors in prostate most cancers cells, affecting tumor proliferation, invasion and cardio glycolysis. As well as, the info of the current examine advised that miR‑663a and mfiR‑1225‑5p had been upregulated in prostate most cancers tissues and cell proliferation of miR‑663a and miR‑1225‑5p knockout PCa cells was considerably decrease in contrast with miR‑NC cells. Moreover, knockout of miR‑1225‑5p and miR‑663a considerably decreased the lactate manufacturing in LNCaP cells in vitro.

In conclusion, the current examine supplied a easy and environment friendly methodology for quickly classifying miRNA operate by making use of CRISPR/Cas9 in LNCaP cells. The current examine advised, for the primary time to the most effective of the authors’ data, that the aberrant expression of miR‑663a and miR‑1225‑5p could also be concerned with the development of prostate most cancers, implying their potential as candidate markers for any such most cancers. Nonetheless, the exact function of miR‑663a and miR‑1225‑5p in accelerating the event of prostate most cancers and selling tumor development stays to be elucidated.

 

hicstatistics
hicstatistics

Genetic and Medical Traits of Sufferers With Homozygous and Compound Heterozygous Familial Hypercholesterolemia From Three Totally different Populations: Case Sequence

  • Homozygous familial hypercholesterolemia (HoFH) and compound heterozygous familial hypercholesterolemia (cHeFH) are uncommon problems generated by disease-causing variants in each alleles of the LDLRor different familial hypercholesterolemia (FH)-related genes. HoFH and cHeFH are characterised by severely elevated low-density lipoprotein-cholesterol (LDL-C), incessantly resulting in early heart problems.

 

  • We investigated the genetic and scientific traits of HoFH and cHeFH sufferers from the Slovenian FH registry and/or those that had been beforehand recognized or managed at our establishment (Slovenian, Pakhtun and Albanian ethnicity), the place genetic testing just isn’t out there. Our examine contains seven sufferers. Their median age on the time of scientific prognosis was 6.three years (2.9-12.9 years); 2/7 had been females.

 

  • Two sufferers had been recognized by the common FH screening and 5 sufferers had been recognized as a result of presence of xanthomas. All of the mutations are current in LDLRgene: 7 completely different genotypes for HoFH (p.Cys167Leu, p.Asp178Asn, p.Cys243Tyr, p.Gly549Asp, p.Cys27Trp, p.Ile585Thr and p.Val797Met) and p.Gly549Asp/p.Gln384Professional genotype for cHeFH affected person. The median preliminary stage of LDL-C was 17.zero mmol/L [655 mg/dL] (vary 7.6-21.6 mmol/L). The HoFH/cHeFH sufferers are clinically and genetically very various.

 

  • The scientific standards (as Simon Broome standards) could be relevant already in youngsters to lift suspicion of FH however in some circumstances fail to tell apart heterozygous FH and HoFH/cHeFH sufferers. Nonetheless, genetic testing is useful in confirming the prognosis, additionally for a immediate consciousness, higher compliance to therapy and household screening.

 

Vav 1 Oncogene (VAV1) Antibody

20-abx329103
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Antibody

abx331549-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Antibody

abx332110-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Antibody

20-abx327434
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Antibody

20-abx327966
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human)

4-PAC213Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1)

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse)

4-PAC213Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1)

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Hu01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P15498
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 61.2kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Vav 1 Oncogene expressed in: E.coli

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Mu01
  • EUR 480.80
  • EUR 232.00
  • EUR 1528.00
  • EUR 576.00
  • EUR 1052.00
  • EUR 385.00
  • EUR 3670.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P27870
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 30.2kDa
  • Isoelectric Point: Inquire
Description: Recombinant Mouse Vav 1 Oncogene expressed in: E.coli

Proto-Oncogene Vav (VAV1) Antibody

20-abx141277
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Proto-Oncogene Vav (VAV1) Antibody

abx011903-100ug 100 ug
EUR 411
  • Shipped within 5-10 working days.

Proto-Oncogene Vav (VAV1) Antibody

20-abx012888
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Proto-Oncogene Vav (VAV1) Antibody

abx239377-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Proto-Oncogene Vav (VAV1) Antibody

20-abx000854
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC

4-PAC213Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Biotinylated

4-PAC213Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Cy3

4-PAC213Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), FITC

4-PAC213Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), HRP

4-PAC213Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), PE

4-PAC213Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC

4-PAC213Mu01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Biotinylated

4-PAC213Mu01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Cy3

4-PAC213Mu01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), FITC

4-PAC213Mu01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), HRP

4-PAC213Mu01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), PE

4-PAC213Mu01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Human Vav 1 Oncogene (VAV1) Protein

20-abx167017
  • EUR 690.00
  • EUR 286.00
  • EUR 2124.00
  • EUR 815.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Mouse Vav 1 Oncogene (VAV1) Protein

20-abx168844
  • EUR 676.00
  • EUR 272.00
  • EUR 2054.00
  • EUR 801.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Proto-Oncogene Vav (VAV1) Protein

20-abx263391
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg
  • Shipped within 5-10 working days.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC-Cy7

4-PAC213Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Leu426~Arg696)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC213Mu01-APC-Cy7
  • EUR 583.00
  • EUR 6610.00
  • EUR 1750.00
  • EUR 778.00
  • EUR 324.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV1 (Gly565~Ala795)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Human Vav 1 Oncogene(VAV1) ELISA Kit

QY-E04499 96T
EUR 361

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx329104
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody

20-abx326674
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx327138
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-100ul 100 ul
EUR 467
  • Shipped within 5-10 working days.

Proto-Oncogene Vav (VAV1) ELISA Kit

abx595617-96tests 96 tests
EUR 637
  • Shipped within 1-2 weeks.

Mouse Proto- oncogene vav, Vav1 ELISA KIT

ELI-17706m 96 Tests
EUR 865

Bovine Proto- oncogene vav, VAV1 ELISA KIT

ELI-51386b 96 Tests
EUR 928

Human Proto- oncogene vav, VAV1 ELISA KIT

ELI-51387h 96 Tests
EUR 824

Human Proto-oncogene vav (VAV1) ELISA Kit

abx384219-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Proto-Oncogene Vav Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx012571
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-VAV1 Antibody

A00691-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for VAV1 Antibody (VAV1) detection. Tested with WB in Human, Mouse, Rat.

Rabbit VAV1 oncogene ELISA kit

E04V0079-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu02
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Antibody

20-abx101251
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Vav 3 Oncogene (VAV3) Antibody

20-abx101252
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Vav 3 Oncogene (VAV3) Antibody

20-abx133365
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Vav 3 Oncogene (VAV3) Antibody

abx433439-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu02-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu02-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu02-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu02-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu02-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu02-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Anti-Vav antibody

STJ96227 200 µl
EUR 197
Description: Rabbit polyclonal to Vav.

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu01
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • EUR 996.00
  • EUR 1892.00
  • EUR 610.00
  • EUR 6820.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q9UKW4
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 24.7kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu02
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • EUR 996.00
  • EUR 1892.00
  • EUR 610.00
  • EUR 6820.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q9UKW4
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 23.2kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Vav Polyclonal Antibody

ABP56489-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human Vav around the non-phosphorylation site of Y174
  • Applications tips:
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ABP56489-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human Vav around the non-phosphorylation site of Y174
  • Applications tips:
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ABP56489-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human Vav around the non-phosphorylation site of Y174
  • Applications tips:
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ES7488-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody

ES7488-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Rabbit Anti-Human Vav1 Polyclonal Antibody, Phospho-Tyr174

CPB-700RH 100 ul
EUR 559

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (His183~Glu380)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu02-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: VAV3 (Phe398~Leu583)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Anti-VAV1 Antibody

A30436 100ul
EUR 397
Description: Rabbit Polyclonal VAV1 Antibody. Validated in ELISA, IF and tested in Human, Mouse, Rat.

anti- VAV1 antibody

FNab09377 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:500
  • IP: 1:500-1:1000
  • Immunogen: vav 1 guanine nucleotide exchange factor
  • Uniprot ID: P15498
  • Gene ID: 7409
  • Research Area: Stem Cells, Immunology, Signal Transduction, Cancer
Description: Antibody raised against VAV1

Anti-VAV1 antibody

PAab09377 100 ug
EUR 412

Anti-VAV1 antibody

STJ11100612 50 µl
EUR 287
Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Anti-VAV1 antibody

STJ117302 100 µl
EUR 277
Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Anti-Vav1 antibody

STJ96228 200 µl
EUR 197
Description: Rabbit polyclonal to Vav1.

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