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Genetic Aberrations of DNA Repair Pathways in Prostate Cancer: Translation to the Clinic
Prostate most cancers (PC) is the second most typical most cancers in males worldwide. Because of the large-scale sequencing efforts, there may be presently a greater understanding of the genomic panorama of PC. The identification of defects in DNA restore genes has led to medical research that present a powerful rationale for growing poly (ADP-ribose) polymerase (PARP) inhibitors and DNA-damaging brokers on this molecularly outlined subset of sufferers.
The identification of molecularly outlined subgroups of sufferers has additionally different medical implications; for instance, we now know that carriers of breast most cancers 2 (BRCA2) pathogenic sequence variants (PSVs) have elevated ranges of serum prostate particular antigen (PSA) at analysis, elevated proportion of excessive Gleason tumors, elevated charges of nodal and distant metastases, and excessive recurrence fee; BRCA2 PSVs confer decrease general survival (OS). Distinct tumor PSV, methylation, and expression patterns have been recognized in BRCA2 in contrast with non-BRCA2 mutant prostate tumors.
A number of DNA injury response and restore (DDR)-targeting brokers are presently being evaluated both as single brokers or together in sufferers with PC. On this overview article, we spotlight the biology and medical implications of deleterious inherited or acquired DNA restore pathway aberrations in PC and provide an outline of recent brokers being developed for the remedy of PC.

Analyzing Plant Gene Focusing on Outcomes and Conversion Tracts with Nanopore Sequencing

The high-throughput molecular evaluation of gene concentrating on (GT) occasions is made technically difficult by the residual presetabce of donor molecules. Giant donor molecules prohibit primer placement, leading to lengthy amplicons that can’t be readily analyzed utilizing customary NGS pipelines or qPCR-based approaches resembling ddPCR. In crops, removing of extra donor is time and useful resource intensive, typically requiring plant regeneration and weeks to months of effort.
Right here, we utilized Oxford Nanopore Amplicon Sequencing (ONAS) to bypass the constraints imposed by donor molecules with 1 kb of homology to the goal and dissected GT outcomes at three loci in Nicotiana benthamia leaves. We developed a novel bioinformatic pipeline, Phased ANalysis of Genome Modifying Amplicons (PANGEA), to cut back the impact of ONAS error on amplicon evaluation and captured tens of 1000’s of somatic plant GT occasions.
Moreover, PANGEA allowed us to gather 1000’s of GT conversion tracts 5 days after reagent supply with no choice, revealing that almost all occasions utilized tracts lower than 100 bp in size when incorporating an 18 bp or three bp insertion. These knowledge reveal the usefulness of ONAS and PANGEA for plant GT evaluation and supply a mechanistic foundation for future plant GT optimization.

Genome Sequence Evaluation of the Fungal Pathogen Fusarium graminearum Utilizing Oxford Nanopore Know-how

Fusarium graminearum is a plant pathogen of world significance which causes not solely important yield loss but additionally crop spoilage as a consequence of mycotoxins that render grain unsafe for human or livestock consumption. Though the complete genome of a number of F. graminearum isolates from completely different elements of the world have been sequenced, there aren’t any comparable research of isolates originating from China.
The present research sought to deal with this by sequencing the F. graminearum isolate FG-12, which was remoted from the roots of maize seedlings exhibiting typical signs of blight rising within the Gansu province, China, utilizing Oxford Nanopore Know-how (ONT). The FG-12 isolate was discovered to have a 35.9 Mb genome comprised of 5 scaffolds comparable to the 4 chromosomes and mitochondrial DNA of the F. graminearum sort pressure, PH-1.
The genome was discovered to comprise an roughly 2.23% repetitive sequence and encode 12,470 predicted genes. Extra bioinformatic evaluation recognized 437 genes that had been predicted to be secreted effectors, certainly one of which was confirmed to set off a hypersensitive responses (HR) within the leaves of Nicotiana benthamiana throughout transient expression experiments using agro-infiltration. The F. graminearum FG-12 genome sequence and annotation knowledge produced within the present research present a particularly helpful useful resource for each intra- and inter-species comparative analyses in addition to for gene purposeful research, and will enormously advance our understanding of this essential plant pathogen.
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Prevalence of Virulence Genes and Antimicrobial Resistance of E. coli O157:H7 Remoted from the Beef Carcass of Bahir Dar Metropolis, Ethiopia

Ecoli O157:H7 is among the most virulent foodborne pathogens. The purpose of this research was to isolate E. coli O157:H7, decide virulence genes carried by the organism, and assess the antimicrobial susceptibility sample of the isolates from beef carcass samples at Bahir Dar metropolis. Swab samples (n = 280) had been collected from the carcass of cattle slaughtered on the abattoir and processed utilizing sorbitol MacConkey agar supplemented with cefixime telluride and confirmed with latex agglutination take a look at.
A polymerase chain response was carried out on isolates for the detection of virulence genes stx1stx2hlyA, and eae. Antimicrobial susceptibility testing was carried out utilizing the disk diffusion technique. Of 280 samples processed, 25 (8.9%) isolates had been optimistic. Out of 25 isolates subjected for molecular detection, 8 (32%) and 14 (56%) isolates possessed stx1 and stx2 genes, respectively; from these, 5 (20%) isolates had each genes for the manufacturing of Shiga toxins.
In contrast from different virulent genes comparatively increased proportion of 18 (72%) isolates carried the hlyA gene. Solely 5 (2%) isolates had been optimistic for eae. Resistance was detected in all 25 (100%) isolates and three (12%) towards clindamycin and trimethoprim, respectively. This research end result highlights the potential risk to public well being. The abattoir staff should be conscious concerning the pathogen and may comply with applicable practices to stop contamination of meat supposed for human consumption.

Genome-scale RNAi screens in African trypanosomes

Genome-scale genetic screens enable researchers to quickly establish the genes and proteins that influence a specific phenotype of curiosity. In African trypanosomes, RNA interference (RNAi) knockdown screens have revealed mechanisms underpinning drug resistance, drug transport, prodrug metabolism, quorum sensing, genome replication, and gene expression management.
RNAi screening has additionally been remarkably efficient at highlighting promising potential antitrypanosomal drug targets. The primary ever RNAi library display was applied in African trypanosomes, and genome-scale RNAi screens and different associated approaches proceed to have a serious influence on trypanosomatid analysis. Right here, I overview these impacts when it comes to each discovery and translation.
The latest software of macroecological instruments and ideas has made it potential to establish constant patterns within the distribution of microbial biodiversity, which enormously improved our understanding of the microbial world at massive scales. Nevertheless, the distribution of microbial capabilities stays largely uncharted from the macroecological perspective. Right here, we used macroecological fashions to look at how the genes encoding the purposeful capabilities of microorganisms are distributed inside and throughout soil methods.
Fashions constructed utilizing purposeful gene array knowledge from 818 soil microbial communities confirmed that the occupancy-frequency distributions of genes had been bimodal in each studied website, and that their rank-abundance distributions had been finest described by a lognormal mannequin. As well as, the relationships between gene occupancy and abundance had been optimistic in all websites.
This allowed us to establish genes with excessive abundance and ubiquitous distribution (core) and genes with low abundance and restricted spatial distribution (satellites), and to indicate that they encode completely different units of microbial traits. Widespread genes encode microbial traits associated to the primary biogeochemical cycles (C, N, P and S) whereas uncommon genes encode traits associated to adaptation to environmental stresses, resembling nutrient limitation, resistance to heavy metals and degradation of xenobiotics.
Total, this research characterised for the primary time the distribution of microbial purposeful genes inside soil methods, and spotlight the curiosity of macroecological fashions for understanding the purposeful group of microbial methods throughout spatial scales.
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The Effect of Water Deficit on Two Greek Vitis vinifera L. Cultivars: Physiology, Grape Composition and Gene Expression during Berry Development
Vegetation are uncovered to quite a few abiotic stresses. Drought might be crucial of them and determines crop distribution world wide. Grapevine is taken into account to be a drought-resilient species, historically overlaying semiarid areas. Furthermore, within the case of grapevine, average water deficit is thought to enhance the standard traits of grape berries and subsequently wine composition.
Nonetheless, in opposition to the backdrop of local weather change, vines are anticipated to expertise sustained water deficits which may very well be detrimental to each grape high quality and yield. The affect of water deficit on two Greek Vitis vinifera L. cultivars, ‘Agiorgitiko’ and ‘Assyrtiko’, was investigated in the course of the 2019 and 2020 vintages. Vine physiology measurements in irrigated and non-irrigated crops have been carried out at three time-points all through berry improvement (inexperienced berry, veraison and harvest).
Berry progress and composition have been examined throughout ripening. In response to the outcomes, water deficit resulted in diminished berry dimension and elevated ranges of soluble sugars, whole phenols and anthocyanins. The expression profile of particular genes, recognized to manage grape coloration, aroma and taste was altered by water availability throughout maturation in a cultivar-specific method.
In settlement with the elevated focus of phenolic compounds attributable to water deficit, genes of the phenylpropanoid pathway within the red-skinned Agiorgitiko exhibited greater expression ranges and earlier up-regulation than within the white Assyrtiko. The expression profile of the opposite genes throughout maturation or in response to water deficit was relied on the classic.

Figuring out Clinicopathological Elements Related to Oncotype DX  21-Gene Recurrence Rating: A Actual-World Retrospective Cohort Examine of Breast Most cancers Sufferers in Quebec Metropolis, Canada

Gene expression profiling assessments such because the Oncotype DX (ODX) 21-gene recurrence rating (RS) assay is more and more utilized in medical follow to foretell the chance of recurrence and assist therapy planning for early-stage breast most cancers (BC). Nonetheless, this check has some disadvantages similar to a excessive value and an extended turnaround time to get outcomes, which can result in disparities in entry. We intention to determine clinicopathological components related to ODX RS in girls with early-stage BC. We performed a retrospective cohort examine of girls recognized within the medical database of the Deschênes-Fabia Breast Illness Middle of Quebec Metropolis College, Canada. Our pattern consists of 425 girls identified with early-stage BC who’ve obtained an ODX RS between January 2011 and April 2015. The ODX RS has been categorized into three ranges as initially outlined: low (0-17), intermediate (18-30), and excessive (>30). The imply RS was 17.8 (SD = 9.2).
Univariate analyses and multinomial logistic regressions have been carried out to determine components related to intermediate and excessive RS in contrast with low RS. A complete of 237 (55.8%) sufferers had low RS, 148 (34.8%) had intermediate RS, and 40 (9.4%) had excessive RS. Girls with progesterone receptor (PR)-negative (ORs starting from 3.51 to 10.34) and histologic grade II (ORs starting from 3.16 to 23.04) tumors have been constantly extra prone to have intermediate or excessive RS than low RS. Comparable patterns of associations have been noticed when the RS was categorised utilizing redefined thresholds from (i.e., from the TAILORx examine or dichotomized).
This examine gives proof suggesting that histologic grade and PR standing are predictive components for intermediate or excessive RS in girls with early-stage BC. If these outcomes are confirmed in future research, contemplating these clinicopathological components may spare girls the necessity to get such a check earlier than the start of a doable adjuvant remedy. This feature may very well be thought of in settings the place the price of testing is a matter.
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Gene Evaluation, Cloning, and Heterologous Expression of Protease from a Micromycete Aspergillus ochraceus Able to Activating Protein C of Blood Plasma

Micromycetes are recognized to secrete quite a few enzymes of biotechnological and medical potential. Fibrinolytic protease-activator of protein C (PAPC) of blood plasma from micromycete Aspergillus ochraceus VKM-F4104D was obtained in recombinant type utilising the bacterial expression system. This enzyme, which belongs to the proteinase-Ok-like proteases, is much like the proteases encoded within the genomes of Aspergillus fumigatus ATCC MYA-4609, A. oryzae ATCC 42149 and A. flavus 28.
Mature PAPC-4104 is 282 amino acids lengthy, preceded by the 101-amino acid propeptide crucial for correct folding and maturation. The recombinant protease was similar to the native enzyme from micromycete by way of its organic properties, together with a capability to hydrolyse substrates of activated protein C (pGlu-Professional-Arg-pNA) and issue Xa (Z-D-Arg-Gly-Arg-pNA) in conjugant reactions with human blood plasma.
Subsequently, recombinant PAPC-4104 can probably be utilized in medication, veterinary science, diagnostics, and different purposes. Useful annotation of unknown operate genes reveals unidentified features that may improve our understanding of advanced genome communications. A typical method for inferring gene operate entails the ortholog-based methodology. Nonetheless, genetic information alone are sometimes not sufficient to offer data for operate annotation.
Thus, integrating different sources of knowledge can probably improve the potential for retrieving annotations. Community-based strategies are environment friendly strategies for exploring interactions amongst genes and can be utilized for practical inference. On this examine, we current an evaluation framework for inferring the features of Plasmodium falciparum genes primarily based on connection profiles in a heterogeneous community between human and Plasmodium falciparum proteins. These profiles have been fed right into a hybrid deep studying algorithm to foretell the orthologs of unknown operate genes.
The outcomes present excessive efficiency of the mannequin’s predictions, with an AUC of 0.89. 100 and twenty-one predicted pairs with excessive prediction scores have been chosen for inferring the features utilizing statistical enrichment evaluation. Utilizing this methodology, PF3D7_1248700 and PF3D7_0401800 have been discovered to be concerned with muscle contraction and striated muscle tissue improvement, whereas PF3D7_1303800 and PF3D7_1201000 have been discovered to be associated to protein dephosphorylation. In conclusion, combining a heterogeneous community and a hybrid deep studying approach can enable us to determine unknown gene features of malaria parasites. This method is generalized and will be utilized to different illnesses that improve the sphere of biomedical science.

 

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The impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemma
Cationic polymers have been broadly studied for non-viral gene supply on account of their means to bind genetic materials and to work together with mobile membranes. Nonetheless, their charged nature carries the danger of elevated cytotoxicity and interplay with serum proteins, limiting their potential in vivo utility. Due to this fact, hydrophilic or anionic shielding polymers are utilized to counteract these results. Herein, a sequence of micelle-forming and micelle-shielding polymers have been synthesized through RAFT polymerization.
The copolymer poly[(n-butyl acrylate)-b-(2-(dimethyl amino)ethyl acrylamide)] (P(nBA-b-DMAEAm)) was assembled into cationic micelles and totally different shielding polymers have been utilized, i.e., poly(acrylic acid) (PAA), poly(4-acryloyl morpholine) (PNAM) or P(NAM-b-AA) block copolymer. These techniques have been in comparison with a triblock terpolymer micelle comprising PAA as the center block. The assemblies have been investigated relating to their morphology, interplay with pDNA, cytotoxicity, transfection effectivity, polyplex uptake and endosomal escape.
The bare cationic micelle exhibited superior transfection effectivity, however elevated cytotoxicity. The addition of protecting polymers led to diminished toxicity. Particularly, the triblock terpolymer micelle satisfied with excessive cell viability and no important loss in effectivity. The very best shielding impact was achieved by layering micelles with P(NAM-b-AA) supporting the colloidal stability at impartial zeta potential and utterly restoring cell viability whereas sustaining reasonable transfection efficiencies. The excessive potential of this micelle-layer-combination for gene supply was illustrated for the primary time.

Genetic Evaluation, Inhabitants Construction, and Characterisation of Multidrug-Resistant Klebsiella pneumoniae from the Al-Hofuf Area of Saudi Arabia

Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is a significant public well being drawback that’s globally related to illness outbreaks and excessive mortality charges. Because the world seeks options to such pathogens, international and regional surveillance is required. The goal of the current research was to look at the antimicrobial susceptibility sample and clonal relatedness of Klebsiella pneumoniae isolates collected for a interval of three years by way of pulse discipline gel electrophoresis (PFGE).
Isolate IDs, antimicrobial assays, ESBL-production, and minimal inhibitory concentrations (MICs) have been examined with the Vitek 2 Compact Automated System. IDs have been confirmed by 16S rRNA gene sequencing, with the ensuing sequences being deposited in NCBI databases. DNA was extracted and resistance genes have been detected by PCR amplification with applicable primers. Isolates have been intensive (31%) and multidrug-resistant (65%).
Pulsotype clusters grouped the isolates into 22 band profiles that confirmed no particular sample with phenotypes. Of the isolates, 98% have been ESBL-KP, 69% have been carbapenem-resistant Enterobacteriaceae (CRE) strains, and 72.5% comprised the carriage of two MBLs (SIM and IMP). Integrons (ISAba1, ISAba2, and IS18) have been detected in 69% of the MDR-KP. Moreover, OXA-23 was detected in 67% of the isolates. This research subsequently demonstrates clonal range amongst scientific Ok. pneumoniae, confirming that this bacterium has entry to an infinite pool of genes that confer excessive resistance-developing potential.

Full Genome Sequencing of Leptospira interrogans Isolates from Malaysia Reveals Large Genome Rearrangement however Excessive Conservation of Virulence-Related Genes

The power of Leptospirae to persist in environments and animal hosts however to trigger clinically extremely variable illness in people has made leptospirosis the most typical zoonotic illness. Contemplating the paucity of knowledge on variation in full genomes of human pathogenic Leptospirae, we’ve used a mix of Single Molecule Actual-Time (SMRT) and Illumina sequencing to acquire full genome sequences of six human scientific L. interrogans isolates from Malaysia.
  • All six contained the bigger (4.28-4.56 Mb) and smaller (0.34-0.395 Mb) chromosome typical of human pathogenic Leptospirae and 0-7 plasmids. Solely 24% of the plasmid sequences could possibly be matched to databases. We recognized a chromosomal core genome of 3318 coding sequences and strain-specific accent genomes of 49-179 coding sequences.
  • These sequences enabled detailed genomic pressure typing (Genome BLAST Distance Phylogeny, DNA-DNA hybridization, and multi locus sequence typing) and phylogenetic classification (whole-genome SNP genotyping). Regardless that there was some shared synteny and collinearity throughout the six genomes, there was proof of main genome rearrangement, doubtless pushed by horizontal gene switch and homologous recombination.
  • Cellular genetic parts have been recognized in all strains in extremely various numbers, together with within the rfb locus, which defines serogroups and contributes to immune escape and pathogenesis. Then again, there was excessive conservation of virulence-associated genes together with these referring to sialic acid, alginate, and lipid A biosynthesis.
  • These findings counsel (i) that the antigenic variation, adaption to numerous host environments, and broad spectrum of virulence of L. interrogans are partially on account of a excessive diploma of genomic plasticity and (ii) that human pathogenic strains keep a core set of genes required for virulence.
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Genomic Analyses of Penicillium Species Have Revealed Patulin and Citrinin Gene Clusters and Novel Loci Concerned in Oxylipin Manufacturing

Blue mildew of apple is attributable to a number of totally different Penicillium species, amongst which P. expansum and P. solitum are essentially the most ceaselessly remoted. P. expansum is essentially the most aggressive species, and P. solitum could be very weak when infecting apple fruit throughout storage. On this research, we report full genomic analyses of three totally different Penicillium species: P. expansum R21 and P. crustosum NJ1, remoted from saved apple fruit; and Pmaximae 113, remoted in 2013 from a flooded house in New Jersey, USA, within the aftermath of Hurricane Sandy. Patulin and citrinin gene cluster analyses defined the shortage of patulin manufacturing in NJ1 in comparison with R21 and lack of citrinin manufacturing in all three strains.
Drosophila bioassay demonstrated that volatiles emitted by Psolitum SA and Ppolonicum RS1 have been extra poisonous than these from Pexpansum and P. crustosum strains (R27, R11, R21, G10, and R19). The toxicity was hypothesized to be associated to manufacturing of eight-carbon oxylipins. Putative lipoxygenase genes have been recognized in Pexpansum and Pmaximae strains, however not in Pcrustosum. Our information will present a greater understanding of Penicillium spp. complicated secondary metabolic capabilities, particularly regarding the genetic bases of mycotoxins and poisonous VOCs.
Pig-to-human xenotransplantation appears to be the response to the up to date scarcity of tissue/organ donors. Sadly, the phylogenetic distance between pig and human implies hyperacute xenograft rejection. On this research, we examined the speculation that combining expression of human α1,2-fucosyltransferase (hFUT2) and α-galactosidase A (hGLA) genes would enable for removing of this impediment in porcine transgenic epidermal keratinocytes (PEKs). We sought to find out not solely the expression profiles of recombinant human α1,2-fucosyltransferase (rhα1,2-FT) and α-galactosidase A (rhα-Gal A) proteins, but in addition the relative abundance (RA) of Galα1→3Gal epitopes within the PEKs stemming from not solely hFUT2 or hGLA single-transgenic and hFUT2×hGLA double-transgenic pigs. Our confocal microscopy and Western blotting analyses revealed that each rhα1,2-FT and rhα-Gal A enzymes have been overabundantly expressed in respective transgenic PEK traces.
Furthermore, the semiquantitative ranges of Galα1→3Gal epitope that have been assessed by lectin fluorescence and lectin blotting have been discovered to be considerably diminished in every variant of genetically modified PEK line as in comparison with these noticed within the management nontransgenic PEKs. Notably, the bi-transgenic PEKs have been characterised by considerably lessened (however nonetheless detectable) RAs of Galα1→3Gal epitopes as in comparison with these recognized for each varieties of mono-transgenic PEK traces. Moreover, our present investigation confirmed that the coexpression of two protecting transgenes gave rise to enhanced abrogation of Galα→3Gal epitopes in hFUT2×hGLA double-transgenic PEKs.
To summarize, detailed estimation of semiquantitative profiles for human α-1,2-FT and α-Gal A proteins adopted by identification of the extent of abrogating the abundance of Galα1→3Gal epitopes within the ex vivo expanded PEKs stemming from mono- and bi-transgenic pigs have been discovered to be a sine qua non situation for effectively ex situ defending steady traces of skin-derived somatic cells inevitable in additional research.
The latter is because of be targeted on figuring out epigenomic reprogrammability of single- or double-transgenic cell nuclei inherited from grownup cutaneous keratinocytes in porcine nuclear-transferred oocytes and corresponding cloned embryos. To our data, this idea was proven to signify a very new strategy designed to generate and multiply genetically reworked pigs by somatic cell cloning for the wants of reconstructive drugs and dermoplasty-mediated tissue engineering of human integumentary system.
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Epigenetic and Genetic Integrity, Metabolic Stability, and Field Performance of Cryopreserved Plants
Cryopreservation is taken into account an excellent technique for the long-term preservation of plant genetic assets. Important progress was achieved over the previous a number of many years, ensuing within the profitable cryopreservation of the genetic assets of various plant species. Cryopreservation procedures typically make use of in vitro tradition methods and require the exact management of a number of steps, such because the excision of explants, preculture, osmo- and cryoprotection, dehydration, freeze-thaw cycle, unloading, and post-culture for the restoration of vegetation.
These processes create a worrying surroundings and trigger reactive oxygen species (ROS)-induced oxidative stress, which is detrimental to the expansion and regeneration of tissues and vegetation from cryopreserved tissues. ROS-induced oxidative stresses had been documented to induce (epi)genetic and somatic variations.
Subsequently, the event of true-to-type regenerants of the supply germplasm is of major concern within the utility of plant cryopreservation know-how. The current article supplies a complete evaluation of epigenetic and genetic integrity, metabolic stability, and discipline efficiency of cryopreserved vegetation developed prior to now decade. Potential areas and the instructions of future analysis in plant cryopreservation are additionally proposed.

Dosage-Dependent Gynoecium Improvement and Gene Expression in Brassica napus-Orychophragmus violaceus Addition Traces

Distant hybridization often results in feminine sterility of the hybrid however the mechanism behind that is poorly understood. Full pistil abortion however regular male fertility was proven by one Brassica napus-Orychophragmus violaceus monosomic alien addition line (MA, AACC + 1 IO, 2n = 39) produced beforehand. To review the impact of a single O. violaceus chromosome addition on pistil improvement in numerous genetic backgrounds, hybrids between the MA and B. carinata (BBCC), B. juncea (AABB), and two artificial hexaploids (AABBCC) had been firstly produced on this research which present full feminine sterility.
A microspore tradition was additional carried out to provide the haploid monosomic alien addition line (HMA, AC + 1 IO, 2n = 20) and disomic addition line (DA, AACC + 2 IO, 2n = 40) along with haploid (H, AC, 2n = 19) and double haploid (DH, AACC, 2n = 38) vegetation of B. napus from MA to analyze the dosage impact of the alien O. violaceus chromosome on pistil improvement and gene expression. In comparison with MA, the event of the pistils of DA and HMA was fully or partially recovered, wherein the pistils might swell and elongate to a traditional form after open pollination, though no seeds had been produced.
Comparative RNA-seq analyses revealed that the numbers of the differentially expressed genes (DEGs) had been considerably totally different, dosage-dependent, and in step with the phenotypic distinction in pairwise comparisons of HMA vs. H, DA vs. DH, MA vs. DH, MA vs. DA, and MA vs. HMA. The gene ontology (GO) enrichment evaluation of DEGs confirmed that a lot of genes concerned within the improvement of the gynoecium, embryo sac, ovule, and integuments. Significantly, a number of frequent DEGs for pistil improvement shared in HMA vs. H and DA vs. DH confirmed capabilities in genotoxic stress response, auxin transport, and signaling and adaxial/abaxial axis specification. The outcomes supplied up to date data for the molecular mechanisms behind the gynoecium improvement of B. napus responding to the dosage of alien O. violaceus chromosomes.

Courting the Frequent Ancestor from an NCBI Tree of 83688 Excessive-High quality and Full-Size SARS-CoV-2 Genomes

All relationship research involving SARS-CoV-2 are problematic. Earlier research have dated the latest frequent ancestor (MRCA) between SARS-CoV-2 and its shut kin from bats and pangolins. Nevertheless, the evolutionary price thus derived is predicted to vary from the speed estimated from sequence divergence of SARS-CoV-2 lineages. Right here, I current relationship outcomes for the primary time from a big phylogenetic tree with 86,582 high-quality full-length SARS-CoV-2 genomes.
  • The tree accommodates 83,688 genomes with full specification of assortment time. Such a big tree spanning a interval of about 1.5 years gives a superb alternative for relationship the MRCA of the sampled SARS-CoV-2 genomes. The MRCA is dated 16 August 2019, with the evolutionary price estimated to be 0.05526 mutations/genome/day.
  • The Pearson correlation coefficient (r) between the root-to-tip distance (D) and the gathering time (T) is 0.86295. The NCBI tree additionally consists of 10 SARS-CoV-2 genomes remoted from cats, collected over roughly the identical time span as human COVID-19 an infection.
  • The MRCA from these cat-derived SARS-CoV-2 is dated 30 July 2019, with r = 0.98464. Whereas the relationship technique is well-known, I’ve included detailed illustrations in order that anybody can repeat the evaluation and acquire the identical relationship outcomes.
  • With 16 August 2019 because the date of the MRCA of sampled SARS-CoV-2 genomes, archived samples from respiratory or digestive tracts collected round or earlier than 16 August 2019, or these that aren’t descendants of the prevailing SARS-CoV-2 lineages, must be significantly invaluable for tracing the origin of SARS-CoV-2.
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Genome-Broad Identification of the HMA Gene Household and Expression Evaluation underneath Cd Stress in Barley

Lately, cadmium (Cd) air pollution in soil has elevated with growing industrial actions, which has restricted crop progress and agricultural improvement. The heavy metallic ATPase (HMA) gene household contributes to heavy metallic stress resistance in vegetation. On this research, 21 HMA genes (HvHMAs) had been recognized in barley (Hordeumvulgare L., Hv) utilizing bioinformatics strategies. Primarily based on phylogenetic evaluation and area distribution, barley HMA genes had been divided into 5 teams (A-E), and full analyses had been carried out by way of physicochemical properties, structural traits, conserved domains, and chromosome localization.
The expression sample evaluation confirmed that almost all HvHMA genes had been expressed in barley and exhibited tissue specificity. In response to the fragments per kilobase of exon per million fragments values in shoots from seedlings on the 10 cm shoot stage (LEA) and phylogenetic evaluation, 5 HvHMA genes had been chosen for expression evaluation underneath Cd stress. Among the many 5 HvHMA genes, three (HvHMA1HvHMA3, and HvHMA4) had been upregulated and two (HvHMA2 and HvHMA6) had been downregulated following Cd remedies. This research serves as a basis for clarifying the capabilities of HvHMA proteins within the heavy metallic stress resistance of barley.

Carbon Dioxide-Derived Biodegradable and Cationic Polycarbonates as a New siRNA Service for Gene Remedy in Pancreatic Most cancers

Pancreatic most cancers is an aggressive malignancy related to poor prognosis and a excessive tendency in growing infiltration and metastasis. Okay-ras mutation is a significant genetic dysfunction in pancreatic most cancers affected person. RNAi-based therapies may be employed for combating pancreatic most cancers by silencing Okay-ras gene expression. Nevertheless, the medical utility of RNAi know-how is appreciably restricted by the dearth of a correct siRNA supply system.
To deal with this hurdle, cationic poly (cyclohexene carbonate) s (CPCHCs) utilizing broadly sourced CO2 because the monomer are subtly synthesized through ring-opening copolymerization (ROCOP) and thiol-ene functionalization. The developed CPCHCs might successfully encapsulate therapeutic siRNA to kind CPCHC/siRNA nanoplexes (NPs). Serving as a siRNA service, CPCHC possesses biodegradability, negligible cytotoxicity, and excessive transfection effectivity. In vitro research exhibits that CPCHCs are able to successfully defending siRNA from being degraded by RNase and selling a sustained endosomal escape of siRNA.
After therapy with CPCHC/siRNA NPs, the Okay-ras gene expression in each pancreatic most cancers cell line (PANC-1 and MiaPaCa-2) are considerably down-regulated. Subsequently, the cell progress and migration are significantly inhibited, and the handled cells are induced into cell apoptotic program. These outcomes exhibit the promising potential of CPCHC-mediated siRNA therapies in pancreatic most cancers therapy.

 

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Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of a variety of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating a variety of injections, and customarily requiring co-selection methods.

 

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by a variety of fold for longer edits. We describe troubleshooting methods that let persistently excessive modifying efficiencies ensuing, as an illustration, in as rather a lot as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the perfect metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

 

Water-Pipe Smoking Publicity Deregulates a Set of Genes Related to Human Head and Neck Most cancers Improvement and Prognosis

  • Water-pipe smoking (WPS) is popping into in all probability probably the most well-liked kind of tobacco use among the many many many youth, notably contained in the Coronary heart East, altering cigarettes quickly and turning into a crucial danger of tobacco dependancy worldwide. Smoke from WPS accommodates comparable toxins as these current in cigarette smoke and is linked instantly with plenty of sorts of cancers together with lung and head and neck (HN) carcinomas.

 

  • Nonetheless, the underlying molecular pathways and/or goal genes accountable for the carcinogenic course of are nonetheless unknown. On this research, human widespread oral epithelial (HNOE) cells, NanoStringPanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain response (qRT-PCR) evaluation had been utilized to hunt out differentially expressed genes (DEG) modulated by WPS. In silico evaluation was carried out to analysis the have an effect on of those genes in HN most cancers affected specific particular person’s biology and consequence. We discovered that WPS can induce the epithelial-mesenchymal transition (EMT: hallmark of most cancers development) of HNOE cells.

 

  • Additional considerably, our evaluation of NanoString revealed 23 genes deregulated beneath the have an effect on of WPS, accountable for the modulation of cell cycle, proliferation, migration/invasion, apoptosis, sign transduction, and inflammatory response. Further evaluation was carried out utilizing qRT-PCR of HNOE WPS-exposed and unexposed cells supported the reliability of our NanoString data.

 

  • Furthermore, we exhibit these DEG to be upregulated in most cancers in distinction with widespread tissue. Utilizing the Kaplan-Meier evaluation, we seen a major affiliation between WPS-deregulated genes and relapse-free survival/full survival in HN most cancers victims. Our findings level out that WPS can modulate EMT together with a set of genes which may very well be instantly concerned in human HN carcinogenesis, thereby affecting HN most cancers victims’ survival.
hicstatistics
hicstatistics

A pilot research on the genetic differ of Mycobacterium tuberculosis troublesome strains from tuberculosis victims contained in the Littoral area of Cameroon

Background: The re-emergence of tuberculosis (TB) worldwide, compounded by multi-drug resistance (MDR) of the causative brokers constitutes a major concern to the administration of the illness. Speedy analysis and correct stress identification are pivotal to the administration of the illness. This pilot research investigated the genetic differ of Mycobacterium tuberculosis troublesome (MTBC) strains from TB victims contained in the Littoral area of Cameroon together with their resistance to rifampicin (RIF).

 

Victims and strategies: This was a cross sectional hospital-based research carried out between January and December 2017 and together with 158 isolates from sputum smear constructive people [105 (66.5%) males and 53 (33.5%) females]. Sputum samples had been examined utilizing Xpert MTB/RIF, adopted by customized on Lowenstein-Jensen medium. Isolates had been additional subjected to molecular characterization utilizing IS6110 typing, deletion evaluation and spoligotyping.

 

Outcomes: 13 (8.8%) of the 147 isolates with susceptibility outcomes accessible had been proof in direction of RIF. Drug resistance occurred in 5/50 (10%) feminine in contrast with 8/97 (8.2%) male (OR, 0.81; 0.25-2.62; p = 0.764), and there was no essential distinction all by means of the age ranges (p = 0.448). Nonetheless, RIF resistance was related (OR, 0.18, 95%CI, 0.05-0.69; p = 0.023) with beforehand handled victims [(4/14 (28.6%)] in contrast with new ones [9/133 (6.8%)].

The 150 acknowledged lineages included amongst others 54 (36%) Cameroon, 18 (12%) UgandaI, 32 (21.3%) Haarlem, 17 (11.3%) Ghana, 9(6%) West African 1, 7(4.7%) Delhi/CAS, 4 (2.7%) LAM and three (2%) UgandaII. Of the 150 isolates, a really highly effective cluster was the Cameroon SIT 61, with 43(28.7%) isolates. Six (35.3%) of the 17 UgandaI sub-lineage had been RIF resistant (OR, 9.58; 95%CI, 2.74-33.55, p = 0.001).

 

Conclusion: The cosmopolitan Littoral area presents with a giant Mycobacterium tuberculosis (MTB) strains differ and the UgandaI sub-lineage attainable related to RIF resistance. Understanding the unfold of this clade by the use of surveillance will improve TB administration contained in the area.

 

Human Pim-1 Oncogene (PIM1) ELISA Kit
DLR-PIM1-Hu-96T 96T
EUR 673
  • Should the Human Pim-1 Oncogene (PIM1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Pim-1 Oncogene (PIM1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Pim-1 Oncogene (PIM1) ELISA Kit
DLR-PIM1-Ra-48T 48T
EUR 549
  • Should the Rat Pim-1 Oncogene (PIM1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Pim-1 Oncogene (PIM1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Pim-1 Oncogene (PIM1) ELISA Kit
DLR-PIM1-Ra-96T 96T
EUR 718
  • Should the Rat Pim-1 Oncogene (PIM1) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Pim-1 Oncogene (PIM1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human Pim-1 Oncogene (PIM1) ELISA Kit
RDR-PIM1-Hu-48Tests 48 Tests
EUR 544
Human Pim-1 Oncogene (PIM1) ELISA Kit
RDR-PIM1-Hu-96Tests 96 Tests
EUR 756
Rat Pim-1 Oncogene (PIM1) ELISA Kit
RDR-PIM1-Ra-48Tests 48 Tests
EUR 583
Rat Pim-1 Oncogene (PIM1) ELISA Kit
RDR-PIM1-Ra-96Tests 96 Tests
EUR 811
Human Pim-1 Oncogene (PIM1) ELISA Kit
RD-PIM1-Hu-48Tests 48 Tests
EUR 521
Human Pim-1 Oncogene (PIM1) ELISA Kit
RD-PIM1-Hu-96Tests 96 Tests
EUR 723
Rat Pim-1 Oncogene (PIM1) ELISA Kit
RD-PIM1-Ra-48Tests 48 Tests
EUR 557
Rat Pim-1 Oncogene (PIM1) ELISA Kit
RD-PIM1-Ra-96Tests 96 Tests
EUR 775
Pim-1 Oncogene (PIM1) Antibody
20-abx101233
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Pim-1 Oncogene (PIM1) Antibody
20-abx101234
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Pim-1 Oncogene (PIM1) Antibody
20-abx101235
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.
Pim-1 Oncogene (PIM1) Antibody
abx146417-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.
Pim-1 Oncogene (PIM1) Antibody
20-abx174066
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug
  • Please enquire.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse)
4-PAC578Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1)
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat)
4-PAC578Ra01
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1)
Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Hu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P11309
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 47.8kDa
  • Isoelectric Point: 5.8
Description: Recombinant Human Pim-1 Oncogene expressed in: E.coli
Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Mu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P06803
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.1kDa
  • Isoelectric Point: 5.6
Description: Recombinant Mouse Pim-1 Oncogene expressed in: E.coli
Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Ra01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P26794
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Pim-1 Oncogene expressed in: E.coli
Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx271779
  • EUR 453.00
  • EUR 244.00
  • EUR 1316.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.
Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx272590
  • EUR 467.00
  • EUR 244.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.
Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx273089
  • EUR 481.00
  • EUR 244.00
  • EUR 1414.00
  • EUR 662.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC
4-PAC578Mu01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Biotinylated
4-PAC578Mu01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Cy3
4-PAC578Mu01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), FITC
4-PAC578Mu01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), HRP
4-PAC578Mu01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), PE
4-PAC578Mu01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with PE.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC
4-PAC578Ra01-APC
  • EUR 364.00
  • EUR 3545.00
  • EUR 980.00
  • EUR 467.00
  • EUR 227.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Biotinylated
4-PAC578Ra01-Biotin
  • EUR 325.00
  • EUR 2658.00
  • EUR 777.00
  • EUR 400.00
  • EUR 225.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Cy3
4-PAC578Ra01-Cy3
  • EUR 444.00
  • EUR 4685.00
  • EUR 1265.00
  • EUR 581.00
  • EUR 261.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), FITC
4-PAC578Ra01-FITC
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), HRP
4-PAC578Ra01-HRP
  • EUR 332.00
  • EUR 3089.00
  • EUR 866.00
  • EUR 421.00
  • EUR 213.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), PE
4-PAC578Ra01-PE
  • EUR 311.00
  • EUR 2856.00
  • EUR 804.00
  • EUR 393.00
  • EUR 202.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.
Human Pim-1 Oncogene (PIM1) Protein
20-abx068546
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.
Rat Pim-1 Oncogene (PIM1) Protein
20-abx068547
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.
Mouse Pim-1 Oncogene (PIM1) Protein
20-abx068548
  • EUR 662.00
  • EUR 272.00
  • EUR 2040.00
  • EUR 787.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat)
4-PAC578Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1)
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC578Mu01-APC-Cy7
  • EUR 583.00
  • EUR 6610.00
  • EUR 1750.00
  • EUR 778.00
  • EUR 324.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr122~Leu261)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC-Cy7
4-PAC578Ra01-APC-Cy7
  • EUR 608.00
  • EUR 6970.00
  • EUR 1840.00
  • EUR 814.00
  • EUR 335.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr38~Leu177)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.
Human Pim-1 Oncogene (PIM1)ELISA Kit
201-12-2345 96 tests
EUR 440
  • This Pim-1 Oncogene ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Human Pim-1 Oncogene (PIM1) CLIA Kit
20-abx190030
  • EUR 7911.00
  • EUR 4215.00
  • EUR 973.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.
Human Pim-1 Oncogene (PIM1) ELISA Kit
20-abx152744
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.
Human Pim-1 Oncogene (PIM1) ELISA Kit
abx573560-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.
Cow Pim-1 Oncogene (PIM1) ELISA Kit
abx519080-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Mouse Pim-1 Oncogene (PIM1) ELISA Kit
abx519082-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.
Rat Pim-1 Oncogene (PIM1) ELISA Kit
abx519083-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.
Human Pim-1 Oncogene(PIM1)ELISA Kit
QY-E04698 96T
EUR 361
Rat Pim-1 Oncogene(PIM1)ELISA Kit
QY-E10539 96T
EUR 400
Human Pim-1 Oncogene ELISA Kit (PIM1)
RK02083 96 Tests
EUR 521
Human Pim-1 Oncogene (PIM1)CLIA Kit
SCC578Hu-10x96wellstestplate 10x96-wells test plate
EUR 5647.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1)CLIA Kit
SCC578Hu-1x48wellstestplate 1x48-wells test plate
EUR 552.76
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1)CLIA Kit
SCC578Hu-1x96wellstestplate 1x96-wells test plate
EUR 746.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1)CLIA Kit
SCC578Hu-5x96wellstestplate 5x96-wells test plate
EUR 3060.6
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1) CLIA Kit
4-SCC578Hu
  • EUR 5698.00
  • EUR 3061.00
  • EUR 747.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Pim-1 Oncogene Clia kit. Alternative names of the recognized antigen: Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Pim-1 Oncogene (PIM1)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Human Pim-1 Oncogene (PIM1) ELISA Kit
SEC578Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1) ELISA Kit
SEC578Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1) ELISA Kit
SEC578Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1) ELISA Kit
SEC578Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Pim-1 Oncogene (PIM1) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-1 Oncogene (PIM1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Human Pim-1 Oncogene (PIM1) ELISA Kit
4-SEC578Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Pim-1 Oncogene elisa. Alternative names of the recognized antigen: Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Pim-1 Oncogene (PIM1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Mouse Pim-1 Oncogene(PIM1)ELISA Kit
QY-E21184 96T
EUR 361
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), APC
4-PAC578Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), Biotinylated
4-PAC578Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), Cy3
4-PAC578Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), FITC
4-PAC578Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), HRP
4-PAC578Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), PE
4-PAC578Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.
ELISA kit for Human PIM1 (Pim-1 Oncogene)
ELK3785 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pim-1 Oncogene (PIM1). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Pim-1 Oncoge
  • Show more
Description: A sandwich ELISA kit for detection of Pim-1 Oncogene from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), APC-Cy7
4-PAC578Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM1 (Tyr129~Leu268)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.
Polyclonal PIM1 / Pim-1 Antibody (aa24-37)
APG01139G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PIM1 / Pim-1 (aa24-37). This antibody is tested and proven to work in the following applications:
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349
Rabbit Pim 1 Oncogene ELISA kit
E04P0753-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Pim 1 Oncogene ELISA kit
E04P0753-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Pim 1 Oncogene ELISA kit
E04P0753-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Proto-oncogene serine/threonine-protein kinase pim-1(PIM1) ELISA kit
CSB-E11825h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Proto-oncogene serine/threonine-protein kinase pim-1 (PIM1) in samples from serum, plasma, tissue homogenates, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Human Proto-oncogene serine/threonine-protein kinase pim-1(PIM1) ELISA kit
1-CSB-E11825h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Proto-oncogene serine/threonine-protein kinase pim-1(PIM1) in samples from serum, plasma, tissue homogenates, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
20-abx214602
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
20-abx125380
  • EUR 495.00
  • EUR 704.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
abx033772-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
abx033772-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
20-abx241258
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
20-abx327418
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.
Serine/Threonine-Protein Kinase Pim-1 (PIM1) Antibody
20-abx302380
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280
Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human)
4-PAN637Hu01
  • EUR 262.00
  • EUR 2747.00
  • EUR 679.00
  • EUR 331.00
  • EUR 220.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM3 (Met1~Leu326)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3)
Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human)
4-PAP797Hu01
  • EUR 262.00
  • EUR 2747.00
  • EUR 679.00
  • EUR 331.00
  • EUR 220.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM2 (Leu82~Glu291)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2)
Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse)
4-PAP797Mu01
  • EUR 266.00
  • EUR 2813.00
  • EUR 694.00
  • EUR 337.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM2 (Gly98~Cys319)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2)
Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat)
4-PAP797Ra01
  • EUR 275.00
  • EUR 2958.00
  • EUR 727.00
  • EUR 350.00
  • EUR 226.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PIM2 (Leu34~Glu292)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2)
hicstatistics
Novel Gene Rearrangement and the Full Mitochondrial Genome of Cynoglossusmonopus: Insights into the Envolution of the Family Cynoglossidae (Pleuronectiformes)

Cynoglossusmonopus, a small benthic fish, belongs to the Cynoglossidae, Pleuronectiformes. It was not usually studied due to its low abundance and cryptical life-style. With the intention to understand the mitochondrial genome and the phylogeny in Cynoglossidae, all the mitogenome of C. monopus has been sequenced and analyzed for the first time. The whole dimension is 16,425 bp, generally containing 37 genes with novel gene rearrangements.

 

The tRNA-Gln gene is inverted from the sunshine to the heavy strand and translocated from the downstream of tRNA-Ile gene to its upstream. The administration space (CR) translocated downstream to the three’-end of ND1 gene adjoining to inverted to tRNA-Gln and left a 24 bptrace fragment inside the genuine place.

 

The phylogenetic timber had been reconstructed by Bayesian inference (BI) and most probability (ML) methods based mostly totally on the mitogenomic info of 32 tonguefish species and two outgroups. The outcomes assist the idea that Cynoglossidae is a monophyletic group and level out that C. monopus has the closest phylogenetic relationship with C. puncticeps.

 

By combining fossil info and mitogenome info, the time-calibrated evolutionary tree of households Cynoglossidae and Soleidae was firstly provided, and it was indicated that Cynoglossidae and Soleidae had been differentiated from each other all through Paleogene, and the evolutionary strategy of family Cynoglossidae coated the Quaternary, Neogene and Paleogene durations.

 

 

The Full Chloroplast Genome of Arabidopsis thaliana Isolated in Korea (Brassicaceae): An Investigation of Intraspecific Variations of the Chloroplast Genome of Korean A. thaliana

 

 

Arabidopsis thaliana (L.) Heynh. is a model organism of plant molecular biology. Higher than 1,700 full genome sequences have been sequenced, nonetheless no Korean isolate genomes have been sequenced to this point though many A. thaliana isolated in Japan and China have been sequenced. To understand the genetic background of Korean pure A. thaliana (named as 180404IB4),

 

we provided its full chloroplast genome, which is 154,464 bp prolonged and has Four subregions: 85,164 bp of giant single copy (LSC) and 17,781 bp of small single copy (SSC) areas are separated by 26,257 bp of inverted repeat (IRs) areas along with 130 genes (85 protein-coding genes, eight rRNAs, and 37 tRNAs). Fifty single nucleotide polymorphisms (SNPs) and 14 insertion and deletions (INDELs) are acknowledged between 180404IB4 and Col0.

 

In addition to, 101 SSRs and 42 extendedSSRs had been acknowledged on the Korean A. thaliana chloroplast genome, indicating an identical number of SSRs on the remaining 5 chloroplast genomes with a alternative of sequence variations in the direction of the SSR space. A nucleotide vary analysis revealed two extraordinarily variable areas on A. thaliana chloroplast genomes. Phylogenetic timber with three additional chloroplast genomes of East Asian pure isolates current that Korean and Chinese language language pure isolates are clustered collectively, whereas two Japanese isolates aren’t clustered, suggesting the need for additional investigations of the chloroplast genomes of East Asian isolates.

 

Loci acknowledged by a genome-wide affiliation study of carotid artery stenosis inside the eMERGE neighborhood

 

Carotid artery atherosclerotic sickness (CAAD) is a risk subject for stroke. We used a genome-wide affiliation (GWAS) technique to seek out genetic variants associated to CAAD in members inside the digital Medical Data and Genomics (eMERGE) Group. We acknowledged grownup CAAD situations with unilateral or bilateral carotid artery stenosis and controls with out proof of stenosis from digital nicely being info at eight eMERGE web sites. We carried out GWAS with a model adjusting for age, intercourse, study web site, and genetic principal components of ancestry.

 

In eMERGE we found 1793 CAAD situations and 17,958 controls. Two loci reached genome-wide significance, on chr6 in LPA (rs10455872, odds ratio [OR] (95% confidence interval [CI]) = 1.50 (1.30-1.73), p = 2.1 × 10-8 ) and on chr7, an intergenic single nucleotide variant (SNV; rs6952610, OR (95% CI) = 1.25 (1.16-1.36), p = 4.3 × 10-8 ). The chr7 affiliation remained very important inside the presence of the LPA SNV as a covariate. The LPA SNV was moreover associated to

 

coronary coronary coronary heart sickness (CHD; 4199 situations and 11,679 controls) on this study (OR (95% CI) = 1.27 (1.13-1.43), p = 5 × 10-5 ) nonetheless the chr7 SNV was not (OR (95% CI) = 1.03 (0.97-1.09), p = .37). Every variants replicated in UK Biobank. Elevated lipoprotein(a) concentrations ([Lp(a)]) and LPA variants associated to elevated [Lp(a)] have beforehand been associated to CAAD and CHD, along with rs10455872. With digital nicely being file phenotypes in eMERGE and UKB, we replicated a beforehand acknowledged affiliation and acknowledged a novel locus associated to CAAD.

Immunophenotypic Landscape and Prognosis of Diffuse Large B-Cell Lymphoma with MYC/BCL2 Double Expression: An Analysis of A Prospectively Immunoprofiled Cohort

Diffuse large B-cell lymphoma (DLBCL) patients with MYC/BCL2 double expression (DE) show poor prognosis and their clinical outcomes after R-CHOP therapy vary immensely. We investigated the prognostic value of DE in aggressive B-cell lymphoma patients (n = 461), including those with DLBCL (n = 417) and high-grade B-cell lymphoma (HGBL; n = 44), in a prospectively immunoprofiled cohort. DE was observed in 27.8% of DLBCLs and 43.2% of HGBLs (P = 0.058). DE-DLBCL patients were older (P = 0.040) and more frequently exhibited elevated serum LDH levels (P = 0.002), higher international prognostic index (IPI; P = 0.042), non-germinal-center B-cell phenotype (P < 0.001), and poor response to therapy (P = 0.042) compared to non-DE-DLBCL patients.
In R-CHOP-treated DLBCL patients, DE status predicted poor PFS and OS independently of IPI (P < 0.001 for both). Additionally, in DE-DLBCL patients, older age (>60 years; P = 0.017), involvement of ³2 extranodal sites (P = 0.021), bone marrow involvement (P = 0.001), high IPI (P = 0.017), CD10 expression (P = 0.006), poor performance status (P = 0.028), and elevated LDH levels (P < 0.001) were significantly associated with poor OS.
Notably, DE-DLBCL patients with normal LDH levels exhibited similar PFS and OS to those of patients with non-DE-DLBCL. Our findings suggest that MYC/BCL2 DE predicts poor prognosis in DLBCL. Risk stratification of DE-DLBCL patients based on LDH levels may guide clinical decision-making for DE-DLBCL patients.
hicstatistics
hicstatistics

Resveratrol relieves chlorothalonil-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in fish kidney cells

Chlorothalonil (CT) is a commonly used fungicide and its excessive application seriously threatens aquatic life and human health. Resveratrol (RSV) is a natural polyphenol and can be used as a therapeutic and preventive agent for the treatment of various diseases. To explore the toxic mechanism of CT exposure on fish kidney cell, as well as the alleviation effect of RSV, we established CT poisoning and/or RSV treatment fish kidney cell models. Ctenopharyngodon idellus kidney (CIK) cell line was treated with CT (5 μg/L) and/or RSV (10 μM) for 48 h.
The results showed that CT exposure activated cytochromeP450s (CYPs) including CYP1A1, CYP1B1 and CYP1C, caused malondialdehyde (MDA) accumulation, inhibited glutathione (GSH) levels and glutathione peroxidase (GPX) activities, increased the expression of miR-15a and downregulated BCL2 and TNFα-induced protein 3 (TNFAIP3, A20), triggered mitochondrial pathway mediated apoptosis and receptor interacting serine/threonine kinase (RIP)-dependent necroptosis in CIK cells.
However, cell death under CT exposure could be relieved by RSV treatment through inhibiting the expression of CYP1 family genes and restoring miR-15a/BCL2-A20 axis disorders. Overall, we conclude that RSV could relieve CT-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in CIK cells. These results enrich the toxicological mechanisms of the CT and confirm that RSV can be used as a potential antidote for CT poisoning.

Mouse Caspase 12 (CASP12) ELISA Kit

RD-CASP12-Mu-96Tests 96 Tests
EUR 677

Anti-Caspase-12/CASP12 Antibody

PA2103 100ug/vial
EUR 334

Caspase 12 (CASP12) Antibody

abx026563-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

abx026563-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

abx216233-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

20-abx213378
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

20-abx210324
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

20-abx100899
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Caspase 12 (CASP12) Antibody

20-abx111421
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

20-abx129818
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Caspase 12 (Casp12) Antibody

20-abx318989
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

20-abx324638
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody

20-abx318255
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse)

4-PAA682Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)

Recombinant Caspase 12 (CASP12)

4-RPA682Mu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: O08736
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 79.6kDa
  • Isoelectric Point: 6.1
Description: Recombinant Mouse Caspase 12 expressed in: E.coli

Recombinant Caspase 12 (CASP12)

4-RPA682Ra01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q920D5
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 31.4kDa
  • Isoelectric Point: 5.1
Description: Recombinant Rat Caspase 12 expressed in: E.coli

Caspase 12 (Casp12) Antibody (HRP)

20-abx318990
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (Casp12) Antibody (FITC)

20-abx318991
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (Casp12) Antibody (Biotin)

20-abx318992
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody (HRP)

20-abx316303
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody (FITC)

20-abx316304
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Antibody (Biotin)

20-abx316305
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC

4-PAA682Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated

4-PAA682Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3

4-PAA682Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC

4-PAA682Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP

4-PAA682Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE

4-PAA682Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat)

4-PAA682Ra01
  • EUR 243.00
  • EUR 2457.00
  • EUR 613.00
  • EUR 305.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12)

Mouse Caspase 12 (CASP12) Protein

20-abx167225
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Rat Caspase 12 (CASP12) Protein

20-abx065753
  • EUR 690.00
  • EUR 286.00
  • EUR 2124.00
  • EUR 815.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA682Mu01-APC-Cy7
  • EUR 538.00
  • EUR 5962.00
  • EUR 1588.00
  • EUR 713.00
  • EUR 304.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Phe413)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC

4-PAA682Ra01-APC
  • EUR 340.00
  • EUR 3203.00
  • EUR 894.00
  • EUR 432.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Biotinylated

4-PAA682Ra01-Biotin
  • EUR 307.00
  • EUR 2407.00
  • EUR 714.00
  • EUR 375.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Cy3

4-PAA682Ra01-Cy3
  • EUR 411.00
  • EUR 4229.00
  • EUR 1151.00
  • EUR 535.00
  • EUR 248.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), FITC

4-PAA682Ra01-FITC
  • EUR 292.00
  • EUR 2582.00
  • EUR 735.00
  • EUR 366.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), HRP

4-PAA682Ra01-HRP
  • EUR 311.00
  • EUR 2792.00
  • EUR 791.00
  • EUR 391.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), PE

4-PAA682Ra01-PE
  • EUR 292.00
  • EUR 2582.00
  • EUR 735.00
  • EUR 366.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with PE.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Rat Casp12/ Caspase-12 ELISA Kit

E0156Ra 1 Kit
EUR 571

Mouse Casp12/ Caspase-12 ELISA Kit

E0211Mo 1 Kit
EUR 571

Human Caspase 12 (CASP12) CLIA Kit

abx196504-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rat Caspase 12 (CASP12) CLIA Kit

abx196787-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Mouse Caspase 12 (CASP12) ELISA Kit

abx254790-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.

Rat Caspase 12 (CASP12) ELISA Kit

abx256323-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.

Mouse Caspase 12 (CASP12) ELISA Kit

20-abx258452
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.

Human Caspase 12 (CASP12) ELISA Kit

20-abx259273
  • EUR 6642.00
  • EUR 3542.00
  • EUR 825.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-12 working days.

Human Caspase- 12, CASP12 ELISA KIT

ELI-02372h 96 Tests
EUR 824

Mouse Caspase- 12, Casp12 ELISA KIT

ELI-02373m 96 Tests
EUR 865

Rat Caspase 12 (CASP12) ELISA Kit

abx353550-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.

Human Caspase 12 (CASP12) ELISA Kit

abx358592-96tests 96 tests
EUR 707
  • Shipped within 5-12 working days.

Mouse Caspase 12 (CASP12) CLIA Kit

20-abx491877
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Human Caspase 12 (CASP12) ELISA Kit

abx513694-96tests 96 tests
EUR 707
  • Shipped within 5-12 working days.

Mouse Casp12(Caspase-12) ELISA Kit

EM0436 96T
EUR 567.6
  • Detection range: 0.156-10 ng/ml
  • Uniprot ID: O08736
  • Alias: Casp12/CASP-12/Caspase-12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Rat Casp12(Caspase 12) ELISA Kit

ER0345 96T
EUR 567.6
  • Detection range: 0.156-10 ng/ml
  • Uniprot ID: Q920D5
  • Alias: Casp12/CASP-12/Caspase-12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

Mouse Caspase 12 (CASP12) ELISA Kit

SEA682Mu-10x96wellstestplate 10x96-wells test plate
EUR 4862.4
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Caspase 12 (CASP12) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit

SEA682Mu-1x48wellstestplate 1x48-wells test plate
EUR 488.08
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Caspase 12 (CASP12) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit

SEA682Mu-1x96wellstestplate 1x96-wells test plate
EUR 654.4
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Caspase 12 (CASP12) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit

SEA682Mu-5x96wellstestplate 5x96-wells test plate
EUR 2644.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Caspase 12 (CASP12) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit

4-SEA682Mu
  • EUR 4913.00
  • EUR 2595.00
  • EUR 655.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Caspase 12 elisa. Alternative names of the recognized antigen: CASP12P1
  • Cysteinyl Aspartate Specific Proteinases 12
  • Apoptosis-Related Cysteine Peptidase
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Caspase 12 (CASP12) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Caspase 12 ELISA Kit (CASP12)

RK02662 96 Tests
EUR 521

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC-Cy7

4-PAA682Ra01-APC-Cy7
  • EUR 560.00
  • EUR 6286.00
  • EUR 1669.00
  • EUR 745.00
  • EUR 315.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CASP12 (Met1~Thr244)
  • Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

CLIA kit for Rat CASP12 (Caspase 12)

E-CL-R0750 1 plate of 96 wells
EUR 584
  • Gentaur's CASP12 CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Rat CASP12. Standards or samples are added to the micro CLIA plate wells and combined with the
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Rat CASP12 (Caspase 12) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat CASP12 (Caspase 12)

E-EL-R0165 1 plate of 96 wells
EUR 534
  • Gentaur's CASP12 ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat CASP12. Standards or samples are added to the micro ELISA plate wells and combined with
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Rat CASP12 (Caspase 12) in samples from Serum, Plasma, Cell supernatant

Human CASP12/ Inactive caspase-12 ELISA Kit

E0355Hu 1 Kit
EUR 571

ELISA kit for Mouse CASP12 (Caspase 12)

ELK7681 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Caspase 12 (CASP12). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Caspase 12 (CA
  • Show more
Description: A sandwich ELISA kit for detection of Caspase 12 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody

CPBT-66303RC 0.1 mg
EUR 580

Casp12 ELISA Kit| Rat Caspase 12 ELISA Kit

EF017215 96 Tests
EUR 689

Casp12 ELISA Kit| Mouse Caspase-12 ELISA Kit

EF013086 96 Tests
EUR 689

Anti-Caspase-12 Antibody

A04700 100ug
EUR 471
Description: Rabbit Polyclonal Caspase-12 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

anti- Caspase 12 antibody

FNab01286 100µg
EUR 505.25
  • Immunogen: caspase 12(gene/pseudogene)
  • Uniprot ID: Q6UXS9
  • Research Area: Metabolism
Description: Antibody raised against Caspase 12

Anti-Caspase 12 antibody

PAab01286 100 ug
EUR 355

Caspase 12 (Caspase 12) Antibody

20-abx007974
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Caspase 12 (Caspase 12) Antibody

abx432451-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Caspase 12 (Caspase 12) Antibody

abx231286-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Polyclonal Caspase-12 Antibody

APR00058G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody

APR06275G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody

APR06276G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Caspase 12 Polyclonal Antibody

ABP50853-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human Caspase12
  • Applications tips:
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody

ABP50853-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human Caspase12
  • Applications tips:
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody

ABP50853-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human Caspase12
  • Applications tips:
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase-12 Rabbit pAb

A0217-100ul 100 ul
EUR 308

Caspase-12 Rabbit pAb

A0217-200ul 200 ul
EUR 459

Caspase-12 Rabbit pAb

A0217-20ul 20 ul
EUR 183

Caspase-12 Rabbit pAb

A0217-50ul 50 ul
EUR 223

Polyclonal Caspase-12 Antibody (Large)

APR06327G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody (Small)

APR06328G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications:

Anti-CASP12 antibody

STJ112891 100 µl
EUR 277

Casp12 Polyclonal Antibody

A50097 100 µg
EUR 570.55
Description: fast delivery possible

Caspase-12 Antibody

24119-100ul 100ul
EUR 390

Caspase-12 Antibody

24120-100ul 100ul
EUR 390

Caspase 12 antibody

20R-1513 100 ug
EUR 673
Description: Rabbit polyclonal Caspase 12 antibody

Caspase 12 antibody

70R-11740 100 ug
EUR 460
Description: Rabbit polyclonal Caspase 12 antibody

Caspase-12 Antibody

3282-100
EUR 354

Caspase-12 Antibody

3282-30T
EUR 146

Caspase 12 antibody

70R-51166 100 ul
EUR 244
Description: Purified Polyclonal Caspase 12 antibody